Hypnotic effect of trazodone. 20, which is 79% off the average retail price of $19.

Hypnotic effect of trazodone Estimates of brain receptor occupancy based on a pharmacokinetic model support the multimodal activity of trazodone, which may contribute to the rapid onset of its antidepressant action and its effectiveness for a variety of symptoms in The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for trazodone hydrochloride tablets and any potential adverse effects on the breastfed child from trazodone hydrochloride tablets or from the underlying maternal condition. 93 for the most common version, by using a GoodRx coupon. NHS medicines information on trazodone – what it's used for, side effects, dosage and who can take it. Pharmacology, adverse reactions, warnings, and Trazodoneside effects. Trazodone (Desyrel) is a medication that treats depression by increasing the amount of serotonin in your brain. Drinking alcohol with this medication can increase the risk of these side effects. Oct 1, 2024 · Trazodone may cause drowsiness, dry mouth, and dizziness in some people. 20 It is known to prolong the cardiac QT-interval. Trazodone is an antidepressant that inhibits serotonin transporter and serotonin type Oct 31, 2023 · Trazodone is a prescription drug for treating depression. Aug 21, 2024 · Trazodone can help you sleep, and sleepiness is a side effect of the medication. Dec 6, 2024 · Trazodone is a prescription drug used to treat depression. , 2020; Sheehan et al. Trazodone (Desyrel - discontinued) treats depression, panic attacks, cocaine withdrawal, and aggressive behavior. Jan 2, 2025 · This article describes the dosages of trazodone, as well as its strengths and how to take it. You can also find information on the drug's strengths, form, and more. Do not drive or operate machinery until you know how this medication affects you. This is associated with a low risk of weight gain, which is rare with trazodone treatment. Read on for a list of common and rare (but serious) trazodone side effects and learn when they may be serious. May 16, 2025 · Trazodone’s dosage for sleep is a classic case of “less is more. Find medical information for trazodone on epocrates online, including its dosing, contraindications, drug interactions, and pill pictures. Learn more. Background: The last few years have seen a remarkable rise in the off-label use of trazodone for inducing sleep in nondepressed patients, to a degree that it is prescribed for this purpose as commonly as the leading hypnotic. Jan 16, 2023 · Trazodone oral tablet is prescribed for depression. Jul 1, 2009 · Background Recent findings indicate that certain classes of hypnotics that target GABAA receptors impair sleep-dependent brain plasticity. This medication may cause dry eyes and blurred vision. Trazodone side effects include headaches, inability to ejaculate, constipation, blurred vision, and fatigue. For temporary relief, use sugarless gum or candy, melt bits of ice in your mouth, or use a saliva substitute. Trazodone hydrochloride is a Sep 11, 2025 · Learn how trazodone works to treat insomnia and depression, and about its side effects, and whether it's right for you. , 2009a). Medscape - Depression, Insomnia-specific dosing for Raldesy (trazodone), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Learn about the common, mild, and serious side effects it can cause and how to manage them. Interactions Medicines that interact with trazodone may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with trazodone. Sep 7, 2020 · Trazodone is a medication used in the management and treatment of major depressive disorder. Feb 29, 2024 · Trazodone is a medication used in the management and treatment of major depressive disorder. However, the effects of hypnotics acting at monoamine receptors (e. Serotonin helps regulate your mood. Avoid negative side effects by not exceeding the maximum daily dose. Includes trazodone side effects, interactions and indications. NHS medicines information on dosage for trazodone, how to take it and what to do if you miss a dose or take too much. In view of this widespread popularity, it seems prudent to review what is known of the safety and efficacy of trazo-done when used in this context. While its longevity means its effects are well studied, trazodone isn’t ideal for all situations. Aug 27, 2025 · Trazodone package insert / prescribing information for healthcare professionals. Learn more about how it is used, interactions, and more. Trazodone is only available as a generic drug; all brands have been discontinued. Dec 15, 2023 · Trazodone treats major depressive disorders. Includes indications, proper use, special instructions, precautions, and possible side effects. Dosage varies by weight. Trazodone is also sometimes used to treat insomnia and schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions); anxiety (excessive worry). Trazodone is part of a class of This medication may affect your coordination, reaction time, or judgment. Aug 21, 2025 · The efficacy and safety of trazodone hydrochloride were established from inpatient and outpatient trials of the trazodone immediate release formulation in the treatment of major depressive 16 HOW SUPPLIED/STORAGE AND HANDLING Trazodone hydrochloride tablets, USP 50 mg are available for oral administration as white, round, biconvex, tablets. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. At higher doses ranging from 150 to 300 mg, trazodone exhibits antidepressant effects as a result of SERT inhibition and 5-HT1A partial agonism (Stahl, 2009a; Fagiolini et al. Read this article to find out more information about trazodone for sleep. g. It may help insomnia caused by depression and anxiety but most experts don't recommend it for other people. Trazodone is associated with a number of side effects. It’s typically prescribed when other antidepressants haven’t been effective or have caused side effects. Trazodone doses between 25 and 150 mg do not achieve antidepressant activity but have hypnotic activity through antagonism of 5-HT 2a, H 1, and α1 receptors. Aug 31, 2021 · The main mechanism through which trazodone promotes sleep is its antagonistic effect on 5-HT2 serotonin receptors, while hypnotics are agonists of gamma-aminobutyric acid GABAA receptors, and other sedative antidepressants block H1 histamine receptors. Mar 14, 2024 · Learn about trazodone usage and dosing. Indications, Mechanism of Action, Administration, Adverse Effects, Contraindications, Monitoring, Toxicity, Enhancing Healthcare Team Outcomes Trazodone is both a selective serotonin reuptake inhibitor (SSRI) and a 5HT2 receptor antagonist and the net result of this action on serotonergic transmission and its role in trazodone’s antidepressant effect is unknown. 21 Memory, alertness, and cognition may be decreased by trazodone, especially in elderly patients due to its central nervous system depressant effects. Generic trazodone is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. This drug is in the serotonin-antagonist-and-reuptake-inhibitor class of medications; it can be used as a component of combination therapy with other drugs or psychotherapies or as monotherapy for treating depression. , the antidepressant trazodone) on this process are unknown. Jul 15, 2024 · Many medications and substances interact with trazodone such as antidepressants, blood thinners, and sedatives like benzodiazepines. However, the benefit of taking trazodone for insomnia is not well established. It comes as an oral tablet and as a generic drug only. 20, which is 79% off the average retail price of $19. Sep 7, 2025 · Trazodone (sold as a generic drug and the brand name Raldesy) is an antidepressant used to treat depression and sleep disorders. Some patients experience light to moderate impairment after taking trazodone. It may be an effective sleep aid with fewer side effects than other options, but it may still pose risks. A guide from Hazelden Betty Ford. The dosage for trazodone depends on what conditions the patient is being treated for. If you need it and do not get side effects, there's no reason to worry about taking trazodone for a long Trazodone prescription and dosage information for physicians and health care professionals. Nov 8, 2024 · Trazodone is an antidepressant often prescribed off-label for sleep. Doctors have used this drug since the 1960s to treat a variety of conditions, including depression, anxiety, and insomnia — although its primary purpose is as an antidepressant. Feb 3, 2024 · Easy-to-read patient leaflet for Trazodone Extended-Release Tablets. Jun 26, 2025 · Trazodone hydrochloride tablets, USP for oral administration contain trazodone hydrochloride, a selective serotonin reuptake inhibitor and 5HT - 2receptor antagonist. However, it may also help with sleeping. We therefore assessed the effects of commonly-prescribed medications for the treatment of insomnia (trazodone and the non Apr 24, 2025 · Trazodone is prescribed off-label to improve sleep. Feb 18, 2025 · Learn about the dosage for trazodone in treating major depressive disorder. 9 A note on priapism Trazodone Trazodone is one of the oldest pharmaceuticals on the market. Trazodone hydrochloride is a triazolopyridine derivative Trazodone is a prescription oral selective serotonin reuptake inhibitor used for treatment of major depressive disorder and other conditions including anxiety and sleep disorders. Trazodone is safe to take for a long time. While there is no body of evidence available to taper trazodone hydrochloride tablets answer the question of how long a patient treated with trazodone hydrochloride and monitor for symptoms (5. Treatment and management. If you wear contact lenses you . QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away. Learn about side effects, warnings, dosage, and more. The American Academy of Sleep Medicine recommends that trazodone and other antidepressants only be used Sep 2, 2023 · Major depressive disorder (MDD) is the most common mood disorder and a leading cause of disability worldwide. May 29, 2024 · Find patient medical information for Trazodone on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Nov 1, 2025 · Taking trazodone together with anesthetic medicines (numbing medicines) that are used during surgery, dental treatments, or emergency treatments may cause an increase in CNS depressant effects. There do not seem to be any lasting harmful effects from taking it for many months, or even years. Nov 11, 2024 · Trazodone is a prescription drug used to treat depression. Here’s a full list. Dec 31, 2024 · Trazodone hydrochloride tablets for oral administration contain trazodone hydrochloride, a selective serotonin reuptake inhibitor and 5HT2 receptor antagonist. Some people need to take trazodone long term to treat depression or anxiety that keeps coming back. Feb 29, 2024 · Point of Care - Clinical decision support for Trazodone. Includes: indications, dosage, adverse reactions and pharmacology. Oct 25, 2007 · Trazodone hydrochloride is an antidepressant chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. Feb 17, 2020 · Includes TraZODone indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse Trazodone is a prescription medication used to treat depression. [28] Because trazodone Oct 10, 2025 · Learn about the side effects of trazodone, from common to rare, for consumers and healthcare professionals. ” Even at a low dose of 1 mg, it helps you get to sleep by starting to block about half of your 5-HT2A receptors. Trazodone is also sometimes used to control abnormal, uncontrollable movements that may be experienced as side effects of other medications and for the management of alcohol The primary use of trazodone is the treatment of unipolar major depression with or without anxiety. Relatively mild side effects include nausea, vomiting, changes in appetite, weight loss or weight gain, muscle pain, dry mouth, dizziness, blurred vision, itching, skin rashes, and constipation. Trazodone interacts with certain medications and alcohol and should be taken only as prescribed. At that point, trazodone not only continues blocking 5-HT2A receptors but also starts to block histamine H1 and alpha-1 adrenergic The side effects are dose-dependent, and the most common is drowsiness. 12). Dec 31, 2015 · Pharmacodynamics Trazodone treats depressed mood and other depression-related symptoms and shows benefit in the treatment of insomnia due to its sedating effects. [4] Data from open and double-blind trials suggest that the antidepressant efficacy of trazodone is comparable to that of amitriptyline, doxepin, and mianserin. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Mar 17, 2025 · traZODone reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI). Trazodone may cause dry mouth. When the risk-benefit ratio of trazodone is assessed, its side effect profile, which is much more significant than that of conventional hypnotics, should be considered. Common trazodone brands names include Desyrel and Desyrel Dividose. Get Trazodone for as low as $4. Jun 7, 2023 · Trazodone hydrochloride tablets, USP for oral administration contain trazodone hydrochloride, USP a selective serotonin reuptake inhibitor and 5HT2 receptor antagonist. Nov 1, 2024 · Is trazodone only used to treat depression? Learn why trazodone is often used off-label to treat sleep issues and how much is considered safe to take. Learn about side effects, use for sleep, dosage, and more. Apr 2, 2025 · Trazodone hydrochloride tablets, USP for oral administration contain trazodone hydrochloride, a selective serotonin reuptake inhibitor and 5HT2 receptor antagonist. Oct 17, 2023 · Trazodone is a drug for treating depression. But its real hypnotic effect comes in when the dose is increased to 25–50 mg. CONCLUSION: A review of the literature suggests that there are adequate data supporting the efficacy and general safety of the low-dose use of trazodone for the treatment of insomnia. Furthermore, trazodone has shown anxiolytic properties, low cardiotoxicity, and relatively mild side effects. Sep 11, 2024 · 7. Keywords: insomnia, hypnotics, treatment, trazodone, sedative Jan 1, 2023 · At low doses, trazodone exhibits sedative-hypnotic effects due to 5-HT2A receptor, H1 receptor, and alpha-1 adrenergic receptor blockade. tablets should continue the drug, it is generally recommended that treatment be continued for several months after an initial response. Learn about side effects, dosages, drug interactions, warnings, and more. Dec 12, 2022 · This information from Lexicomp® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider. Trazodone, a triazolopyridine serotonin receptor antagonist and reuptake inhibitor (SARI) antidepressant approved for major depressive disorder (MDD) in adults, has established efficacy that is comparable to other available antidepressants, and is effective for a range of depression In summary, there are few data to support the use of trazodone in nondepressed subjects. It also has side effects, even when prescribed by a Nov 6, 2022 · Trazodone is a type of tricyclic-related antidepressant that is used to treat depression and anxiety in adults. Trazodone may cause a condition that affects the heart rhythm (QT prolongation). Based on limited data, the antidepressant effect of usual dosages of trazodone appears to be greater than that of amitriptyline or imipramine in these patients. Doctors will sometimes prescribe trazodone for insomnia, particularly for people who have both depression and difficulty sleeping. Apr 4, 2019 · Trazodone is a prescription antidepressant medication. Jan 1, 2025 · Trazodone is a tetracyclic antidepressant used to treat depression and anxiety disorders. To learn more about trazodone, including its uses and side effects, see this trazodone overview article. Nov 22, 2022 · Trazodone (Desyrel) is an antidepressant drug used to treat symptoms of major depressive episodes. Trazodone has been used in patients with major depression who have associated anxiety. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. wzesua gyp tif qun bac dnkobl bismow yvqi vogzv skueioav dkcvm eecmpm svqk uodsfo tvamy