Superscan prostate cancer

Superscan prostate cancer. Prostate cancer is the most common malignancy associated with superscan along with others such as lung cancer, breast cancer and haematological malignancies. PCa bone metastasis is mainly osteosclerotic Superscan Causes of Superscan • Metastatic disease – Prostate, breast, lung most common. In these retrospective case series, we performed SPECT with A 76-year-old man presented with recently diagnosed prostate adenocarcinoma, Gleason score of 4 + 4, and a Super bone scan with concurrent PSA of 1. Diagnosis. The diagnosis is usually established by a combination of imaging and the known presence of a primary tumour associated with sclerotic bone metastases. 178 Jun 2, 2015 · ASCO - Prostate Cancer Working Group 3 (PCWG3) consensus for trials in castration resistant prostate cancer - Session Highlights Published 02 June 2015 CHICAGO, IL USA (UroToday. org (Accessed on 01 Apr 2024) https://doi. – Multiple myeloma and renal adenocarcinoma usually do not show increased uptake. Jul 18, 2024 · Epidemiology. Superscan is most frequently seen in prostate cancer, but numerous other cancers and metabolic bone diseases can cause superscan, which should be kept in mind when encountering an unexpected superscan on BS. 2 Therefore, significant renal and bladder radioactivity are normal in most scans. Among papers with malignant cause, prostate cancer was the most common cause, followed by gastric cancer. org (Accessed on 14 Nov 2023) https://doi. A 63-year-old man with metastatic prostate carcinoma underwent Ga-PSMA PET/CT imaging for staging and Out of 6027 patients referred for bone scan, 307 patients had prostate cancer on histopathological examination. 18F-FDG PET/CT Superscan in Prostate Cancer. Incontinence. 5 mg/dL), high serum ferritin Prostate cancer is one of the most common cancers affecting men. To evaluate the accuracy of standard whole body planar images (superscan) in conjunction with xSPECT reconstruction images in detecting and diagnosing bone metastases in patients with prostate cancer. The whole-body image count alone, with little or no additional processing, is a helpful discriminator for the nuclear medicine superscan. Stanislavsky A, Diffuse bone metastases - prostate cancer. How … Excessive skeletal radioisotope uptake in relation to soft tissues along with absent or faint activity in the genitourinary tract on skeletal scintigraphy is known as a "superscan. A superscan on Tc-99m bone scintigraphy is described in multiple skeletal metastatic disease. " Skalski M, Osteoblastic metastases from prostate cancer. Jun 23, 2021 · Prostate-specific membrane antigen (PSMA) is a transmembrane glutamate carboxypeptidase that is highly expressed on prostate cancer cells. • Metabolic disease – Renal osteodystrophy, Paget’s disease, hyperparathyroidism – Less common: Hyperthyroidism, hypervitaminosis D – Rare: Osteopetrosis Keywords: Prostate cancer; Ga-68 PSMA; Superscan Case Report Prostate cancer (PCa) is the most frequent tumor in men worldwide and prostate cancer most often spreads to bone, commonly leading to bone pain [1]. Prostate cancer is the most common cause of superscan in skeletal scintigraphy due to diffuse skeletal metastases. Jan 1, 2024 · Introduction. A. This may assist the identification of this relatively uncommon diffuse metastatic disease in men with prostate cancer and reduce the number of investigations that … Jan 1, 2021 · A study of 307 prostate cancer patients reported that 15% demonstrated superscan appearances, of which 72% of the same group (15%) had serum PSA levels of 178 ng/ml and 122 ng/ml in symptomatic and asymptomatic patients respectively (Manohar et al. Superscan met prostate cancer. Physical examination revealed generalised bone tenderness with associated indirect pain; digital rectal examination indicated asymmetric prostatic induration. eCarboplatin was given as part of a taxane regimen. A bone scan with diffused increased skeletal tracer uptake relative to soft tissue, combined with faint renal activity is known as a superscan. The diagnosis is usually established by a combination of imaging and the known presence of a primary tumor associated with sclerotic bone metastases. 53347/rID-45759 Mar 19, 2008 · The . Intense osteoblastic activity in the bones causes diminished renal and background soft t May 11, 2020 · Objection We aimed to evaluate the role of bone scintigraphy (BS) which has long been the imaging modality of choice in prostate cancer (PCa) and performed a head-to-head comparison between BS, BS + SPECT/CT and 68 Ga-PSMA-PET/CT, for the detection of bone metastasis of PCa. 73% (33/46) prostate cancer patients with superscan had Gleason score of 8 and above 8 with mean serum prostate-specific Sep 15, 2022 · Positron emission tomography (PET) combined with computed tomography (PET/CT) or magnetic resonance imaging (PET/MRI) using several radiopharmaceuticals—particularly prostate-specific membrane antigen (PSMA)-targeting radiopharmaceuticals—are new-generation imaging modalities for prostate cancer (PC) staging and restaging. Before sharing sensitive information, make sure you’re on a federal government site. 68Ga-PSMA-11 The pattern of diffuse increased skeletal uptake with no tracer seen in the kidneys/bladder is called a "superscan". Jan 22, 2024 · The superscan effect presents a technical challenge in the evaluation of lesions on bone scans in prostate cancer clinical trials. CASE 17 Clinical Presentation. 68 Ga-PSMA ligand in PET/CT revealed a PSMA over expression of diffuse sclerotic lesions extended to axial and appendicular gastric cancer and up to 23% in a cohort of prostate cancer patients. Dec 14, 2022 · Lung cancer, breast cancer, renal cell carcinoma, and prostate cancer account for ~80% of all bone metastases 1. g Following an amendment, superscan participants are excluded. We describe the finding of a metastatic superscan detected by Ga-PSMA PET/CT imaging. 73% (33/46) prostate cancer patients with superscan had Gleason score of 8 and above 8 with mean serum prostate-specific Aug 11, 2024 · The aim of prostate MRI is to detect clinically significant prostate cancer, as insignificant prostate cancer is common 35. A superscan pattern on the initial whole-body bone scan suggested extensive disease. The patient responded well to definitive treatment, exhibiting clinical improvement based on decreased PSA Dec 1, 2023 · This report presents the imaging findings in a patient with advanced prostate cancer and bone metastases. Out of 307 patients with prostate cancer, 46 had superscan appearance. Laboratory examination revealed high serum alkaline phosphatase (1348 U/L (bone type, 73. If a patient has lower back pain, an elevated PSA, and a positive prostate biopsy with a Gleason score of 8, and he also has a positive bone scan showing accumulation of tracer in his lower spine and pelvis, it’s a pretty safe bet that the bone scan is showing metastatic prostate cancer. Location The distribution of skeletal metastases roughly mirrors the distribution of red marrow , presumably reflecting increased blood flow in red marrow compared to yellow marrow 8 : The total counts acquired during the scan were used to compare the skeletal uptake of the radiopharmaceutical between prostate patients showing superscan image patterns (n=38), prostate cancer The ¹⁷⁷Lu-labeled prostate-specific membrane antigen (LuPSMA) radionuclide therapy for metastatic castration-resistant prostate cancer is under investigation in a phase III trial (VISION: NCT03511664). Methods We evaluated 138 PCa patients who underwent BS and 68 Ga-PSMA PET/CT and SPECT/CT of 102 of 138 patients. This report presents the imaging findings in a patient with advanced prostate cancer and bone metastases. Although PET radiotracers generally have higher sensitivity and spatial resolution, SPECT tracers can be an effective alternative when PET/CT systems are unavailable in the clinical setting. The frequency of superscans ranged from 1. Posted on March 6, 2020 October 15, 2023 by Edward Gillis. , 2017). Only three out of eight patients who died of diseases other than prostate cancer had an observation time shorter than 24 months (4, 10 and 12 months). Intense osteoblastic activity in the bones causes diminished renal and background soft t The extensive innumerable osteoblastic metastases involving the axial and appendicular skeletons resulting in a superscan appearance. 98% (46/307), and 71. 2024) and has been defined as one or more of the following (noting variability within criterion) 31-35 : Jan 1, 2017 · Request PDF | Superscan Imaging on Ga-68 PSMA PET/CT in Prostate Cancer Patient | Prostate cancer (PCa) is the most frequent tumor in men worldwide. 53347/rID-84471 Aug 7, 2024 · A superscan is an imaging appearance on a Tc-99m diphosphonate bone scan which occurs as a result of a high ratio of bone to soft tissue tracer accumulation. Ligand PET/CT in Prostate Cancer-Diagnostic Criteria and Its Significance Abstract Superscan in 68Ga-PSMA ligand PET/CT is not very commonly encountered in prostate cancer patients. Here we present the case of a 41 year old woman with carcinoma colon with metastatic superscan on 99m Tc-MDP bone scintigraphy, a very rare cause for metastatic superscan. Images Sep 1, 2015 · Images demonstrated diffuse and extensive skeletal uptake in the axial and appendicular skeleton, corresponding to the typical red marrow distribution, in a 63-year-old man with metastatic prostate carcinoma. Approximately 3. However, this term is without a consensus definition 35,36 (c. 1 There is a wide range Jan 24, 2016 · Visit the post for more. A 76-year-old man presented with recently diagnosed prostate adenocarcinoma, Gleason score of 4 + 4, and a Super bone scan with concurrent . Prostate cancer (46/80) was the most common cause of superscan appearance followed by breast cancer (10/80). }, author={Ew-Jun Chen and Teik Hin Tan and Ming Tsuey Chew}, journal={Radiation Physics and Chemistry Jan 19, 2022 · A superscan is an imaging appearance on a Tc-99m diphosphonate bone scan which occurs as a result of a high ratio of bone to soft tissue tracer accumulation. 5 months later, an F-fluciclovine PET/CT was performed despite of a decreased PSA of 0. org/10. 73% (33/46) prostate cancer patients with superscan had Gleason score of 8 and above 8 with Apr 18, 2023 · Incidence of superscan in prostate cancer was 14. Laboratory findings showed signs of acute liver failure, and marked elevation of lactate dehydrogenase and tumor marker levels. 53347/rID-12361 Jun 14, 2024 · If you're diagnosed with prostate cancer, you may be referred to a cancer specialist (oncologist) or a specialist who uses radiation therapy to treat cancer (radiation oncologist). F-FDG PET/CT of a patient with inflammatory lower back pain reveals diffuse bony metastases, similar to the Aug 14, 2023 · If the kidneys and bladder are not seen, this should raise suspicion of the so-called “superscan. org (Accessed on 09 Mar 2024 Mar 1, 2011 · This is a report of bone scintigraphy demonstrating superimposed metastatic and metabolic superscan in a patient with prostate cancer, who subsequently developed renal osteodystrophy. 6% in patients with gastric cancer and up to 23% in a cohort of prostate cancer patients. A technetium-99m methyl diphosphonate bone superscan demonstrating intense, diffuse uptake in the axial and proximal appendicular skeleton as well as more focal uptake in the calvarium in this patient with metastatic prostate adenocarcinoma. Bailly and others published Le superscan métabolique en TEP/TDM au 18F-FDG : à propos d’un cas de cancer de prostate | Find, read and cite all the research you need on Feb 21, 2014 · Positron emission tomography/computed tomography (PET/CT) is widely used in prostate cancer to evaluate the localized tumor burden and detect symptomatic metastatic lesions early. 53347/rID-31766 Mar 24, 2020 · Metastatic bone disease (MBD) is common—it is detected in up to 65–75% of patients with breast or prostate cancer, in over 35% of patients with lung cancer; and almost all patients with symptomatic multiple myeloma have focal lesions or a diffuse bone marrow infiltration. We present a case At initial presentation, review of slides and blocks of prostatic core biopsies (done in another hospital) showed prostatic adenocarcinoma in all core biopsies. However, patients with diffuse bone involvement, diagnosed with a "superscan" by bone s … ESMO 2022 177-Lutetium (Lu)-PSMA for prostate cancer treatment, 68Ga-PSMA-11 PET/CT + Lu-PSMA therapy, diagnostics and treatment of prostate cancer, Lu-PSMA in prostate cancer, TheraP trial, VISION trial, post-androgen receptor pathway inhibitor. Dec 28, 2023 · We describe a case series of seven patients with prostate cancer from the National Institute of Cancerology in Colombia, in which a super scan pattern was found in the evaluation with 68 Ga-PSMA PET/CT, proposing the suppression of uptake in the intestine, liver, spleen, lacrimal and salivary glands as the main criteria for its definition, and Jan 1, 2021 · This study aims to evaluate the accuracy of a superscan as defined above, with combination of 3D SPECT/CT reconstructed images for detecting and diagnosing bone metastases in prostate cancer patients. 2014, Clinical Nuclear Medicine. Feb 2, 2022 · Superscan Appearance of 68 Ga PSMA PET/CT in a Patient with Refractory Prostate Cancer Refrakter Bir Prostat Karsinomu Olgusunun 68 Ga PSMA PET/BT’de Superscan Görünümü Zehra Pınar Koç , 1, * Pınar Pelin Özcan , 1 Vehbi Erçolak , 2 and Mehmet Reyhan 3 Jan 1, 2021 · DOI: 10. ” A superscan implies diffusely increased osseous uptake due to metastatic disease (most commonly breast or prostate cancer) or metabolic bone disease which is so intense that little or no renal excretion of the radiotracer occurs. mil. KEYWORDS benign, bone scintigraphy, cancer, metabolic Apr 19, 2022 · Imaging of metastatic castrate-resistant prostate cancer to select patients suitable for peptide receptor radioligand therapy can be performed with both SPECT and PET PSMA radiotracers. Once prostate cancer has spread to other areas of the body, it may still respond to treatment and may be controlled, but it's unlikely to be cured. Howard Scher of Memorial Sloan Kettering presented the Prostate Cancer Working Group 3 (PCWG3) Consensus Guidelines, an update from the previously published Jan 1, 2003 · The mean follow-up for those patients who did not die because of prostate cancer was 36 months (median, 33; range, 4–86). None of the patients were lost to follow-up during this analysis. Oct 1, 2014 · F-FDG PET/CT of a patient with inflammatory lower back pain reveals diffuse bony metastases, similar to the "superscan" found on a Tc-methylene diphosphonate scintigraphy, and also demonstrates a prostatic lesion which appears to be a poorly differentiated prostate adenocarcinoma. Sep 26, 2023 · This report presents the imaging findings in a patient with advanced prostate cancer and bone metastases. Prostate cancer is the most common cancer in men in the United States. Sep 16, 2014 · Super bone scan is a special condition of extremely high bone uptake relative to soft tissue with absent renal radioactivity visualisation (‘absent kidney sign’). Bone scan is part of the staging modality commonly used to evaluate bone metastasis. Nov 23, 2023 · Purpose This study aims to establish and validate a new diagnosis model called P. Conclusion: Superscan is most frequently seen in prostate cancer, but numerous other cancers and metabolic bone diseases can cause superscan, which should be kept in mind when encountering an unexpected superscan on BS. The superscan imaging appearance occurs as a result of a high ratio of bone to soft tissue tracer accumulation. Intense osteoblastic activity in the bones causes diminished renal and background soft t Furthermore, the criteria of a superscan can sometimes yield inconclusive results. Superscan Superscan: intense symmetric uptake of radiotracer by the skeletal system with relative decreased uptake by the bladder, kidneys, and soft tissues Differential diagnosis for superscan: • Metastatic disease (prostate, breast, transitional cell carcinoma) • Metabolic bone disease (hyperparathyroidism, renal osteodystrophy, osteomalacia) Technetium-99m methyl diphosphonate bone superscan. Gleason grade = 7a (3 + 4). The FDA approved the drug for positron emission tomography (PET) imaging of PSMA-positive lesions in men with prostate cancer. 1016/j. , docetaxel and cabazitaxel), immunotherapy (e. }, author={Ew-Jun Chen and Teik Hin Tan and Ming Tsuey Chew}, journal={Radiation Physics and Chemistry Apr 6, 2022 · Purpose Actinium-225-labeled prostate-specific membrane antigen ([225Ac]Ac-PSMA-617) is safe and effective in the treatment of metastatic castration-resistant prostate cancer (mCRPC). g. Mar 30, 2021 · Prostate-specific membrane antigen (PSMA)–targeted radiopharmaceuticals are playing a large role at the time of initial staging and biochemical recurrence for localizing prostate cancer, as well as in other emerging clinical settings. radphyschem. A superscan on May 29, 2023 · Prostate-specific membrane antigen (PSMA) is expressed by the majority of clinically significant prostate adenocarcinomas, and patients with target-positive disease can easily be identified by PSMA PET imaging. 2020. Ew-JunChen, Teik HinTan, Ming TsueyChew 2021 | Radiation Physics and Chemistry, Vol. com) - Dr. Age, prostate-specific antigen (PSA), free/total PSA (f/tPSA), PSA density (PSAD), peripheral zone volume ratio (PZ-ratio), and adjusted PSAD of PZ (aPSADPZ) were Related articles Superscan Prostate carcinoma PDF | On May 1, 2014, M. 8,9 High PSMA expression is an independent biomarker of Superscan in 68 Ga-PSMA ligand PET/CT is not very commonly encountered in prostate cancer patients. 68Ga-PSMA ligand in PET/CT revealed gastric cancer and up to 23% in a cohort of prostate cancer patients. Primary Endpoint: PSA50 Response • PSA50 was achieved in 10/20 participants (50%), regardless of prior Lu treatment (Figure 4) A 69-year-old man with prostate cancer presented to the hospital with 2 weeks' history of fever, abdominal distension, and fatigue. We aimed to investigate the hematologic toxicity and efficacy of [225Ac]Ac-PSMA-617 therapy in patients with The pattern of diffuse increased skeletal uptake with no tracer seen in the kidneys/bladder is called a "superscan". KEYWORDS benign, bone scintigraphy, cancer, metabolic Feb 1, 2008 · The most significant factors associated with the «superscan» scintigraphy phenomenon in prostate cancer patients were the primary tumor extension, high PSA level and low-grade tumors. Metastatic superscan in prostate carcinoma on gallium-68-prostate-specific membrane antigen positron emission tomography/computed tomography scan Krishan Kant Agarwal , Madhavi Tripathi , Rajeev Kumar , and Chandrasekhar Bal Prostate cancer (46/80) was the most common cause of superscan appearance followed by breast cancer (10/80). @article{Chen2021SuperscanSO, title={Superscan: Superiority of xSPECT/CT over OSEM SPECT/CT in bone scans of prostate cancer patients. Jun 19, 2018 · Superscan in 68 Ga-PSMA ligand PET/CT is not very commonly encountered in prostate cancer patients. 1 While the overall prognosis of men diagnosed with prostate cancer is excellent, prostate cancer is also the second leading cause of cancer-related mortality in men in the United States, as a large subset of patients will have progressive disease to which they will ultimately succumb. Continue Reading Jul 18, 2024 · Epidemiology. }, author={Ew-Jun Chen and Teik Hin Tan and Ming Tsuey Chew}, journal={Radiation Physics and Chemistry Jan 1, 2021 · DOI: 10. No study has specifically assessed its safety in patients with extensive skeletal metastases of mCRPC. This type of scan results in the characteristically high boneto-soft tissue ratio in image intensity. org (Accessed on 29 Jul 2024) https://doi. Intense osteoblastic activity in the bones causes diminished renal and background soft tissue uptake. There are two main differentials - diffuse skeletal metastases and hyperparathyroidism. dSuperscan status was determined via Technetium-99m bone scan. We present a 70-year-old patient with an elevated PSA serum level of 638 ng/mL after chemo-therapy for prostate cancer. Incidence of superscan in prostate cancer was 14. score for clinically significant prostate cancer (csPCa). 7 ng/mL; a Superscan fluciclovine PET/CT was identified, and bone metastasis were later confirmed at biopsy. Z. Bone metastases are the most common bone malignancy, with sclerotic bone metastases being less common than lytic bone metastases. Superscan appearance can sometimes be difficult to spot but is easy to make when the absent renal uptake is noticed. Mar 1, 2003 · Superscan: Superiority of xSPECT/CT over OSEM SPECT/CT in bone scans of prostate cancer patients. A 72-year-old man with a history of metastatic prostate cancer is referred for a bone scan because of pain in the left shoulder and lower neck (). After a detailed literature search, we did not find similar cases in the literature with 99m Tc-PSMA imaging. Jan 19, 2022 · A superscan is an imaging appearance on a Tc-99m diphosphonate bone scan which occurs as a result of a high ratio of bone to soft tissue tracer accumulation. Apr 30, 2020 · Incidence of superscan in prostate cancer was 14. org (Accessed on 13 Nov 2023) https://doi. Sep 26, 2023 · A superscan pattern on the initial whole-body bone scan suggested extensive disease. 68 Ga-PSMA ligand in PET/CT revealed a PSMA over expression of diffuse sclerotic lesions extended to axial and appendicular Apr 29, 2019 · Up to 90% of men with metastatic castration-resistant prostate cancer (mCRPC) will have a distribution of disease that includes bone metastases demonstrated on a Technetium-99m (99mTc-MDP) bone scan. 1,2,3 After lungs and liver, bone is the third most common site of metastasis; 80% of bone malignancies are Prostate cancer skeletal metastases - superscan Ashraf A, Prostate cancer skeletal metastases - superscan. Jun 14, 2024 · Prostate cancer that spreads to the bones can cause pain and broken bones. Metastatic bone disease can cause a variety of symptoms and is often associated with a poorer prognosis, with high In the US, about 350,000 patients with cancer will develop bone metastases each year. gov or . Jan 3, 2018 · Treatment options for metastatic castration-resistant prostate cancer (mCRPC) have expanded in recent years and include cytotoxic agents (e. 18F-FDG is the F-FDG PET/CT of a patient with inflammatory lower back pain reveals diffuse bony metastases, similar to the "superscan" found on a Tc-methylene diphosphonate scintigraphy, and also demonstrates a prostatic lesion which appears to be a poorly differentiated prostate adenocarcinoma. Jan 1, 2021 · DOI: 10. Bickle I, Superscan: prostate cancer. helene besse. Two years after the first bone scintigraphy showing multiple metastases, the patient developed renal insufficiency, hyperphosphoremia, and hypocalcemia. The patient responded well to definitive treatment, exhibiting clinical improvement based on decreased PSA levels and CT findings in 6-month follow-up. The new prostate-specific membrane antigen (PSMA) PET imaging will significantly improve how prostate cancer is detected and treated. Both prostate cancer and its treatment can cause urinary incontinence. Case study, Radiopaedia. Abdominal CT showed hepatomegaly with mu … Offering breakthrough diagnostics for prostate cancer treatment Prostate cancer is one of the most common cancers in men. Because appointments can be brief, and because there's often a lot of information to discuss, it's a good idea to be prepared. We present a 70-year-old patient with an elevated PSA serum level of 638 ng/mL after chemotherapy for prostate cancer. Methods The demographic and clinical characteristics of 956 patients were recorded. 7 ng/mL. gov means it’s official. This entry was posted in Endocrine A 75-year-old man presented with a 2-month history of worsening chest and back pain. PSMA PET has demonstrated increased detection rate compared with conventional imaging and has been shown to change management plans in a substantial percentage Mar 6, 2020 · Superscan metastatic prostate cancer. }, author={Ew-Jun Chen and Teik Hin Tan and Ming Tsuey Chew}, journal={Radiation Physics and Chemistry This report presents the imaging findings in a patient with advanced prostate cancer and bone metastases. Federal government websites often end in . A Superscan fluciclovine PET/CT … Apr 19, 2022 · A skeletal ‘superscan’ in patients with prostate cancer has been demonstrated in the literature with 18 F-choline PET/CT and 68 Ga-PSMA PET/CT imaging. Perineural invasion: identified in core biopsy of right m This is a report of bone scintigraphy demonstrating superimposed metastatic and metabolic superscan in a patient with prostate cancer, who subsequently developed renal osteodystrophy. Apr 1, 2019 · A 76-year-old man presented with recently diagnosed prostate adenocarcinoma, Gleason score of 4 + 4, and a Super bone scan with concurrent PSA of 1. Out of 6027 patients referred for bone scan, 307 patients had prostate cancer on histopathological examination. . 3 ng/mL. Intense osteoblastic activity in the bones causes diminished renal and background soft t Apr 18, 2023 · Superscan is most frequently seen in prostate cancer, but numerous other cancers and metabolic bone diseases can cause superscan, which should be kept in mind when encountering an unexpected superscan on BS. 73% (33/46) prostate cancer patients with superscan had Gleason score of 8 and above 8 with mean serum prostate-specific Dec 28, 2023 · Prostate cancer is the second most common malignancy in men worldwide, with a good prognosis when is detected and treated in early stages, but, when it presents progression to castration-resistant metastatic prostate cancer, most of the cases will have bone metastasis, decreasing the quality of life … May 28, 2020 · Incidence of superscan in prostate cancer was 14. 2%)), high C reactive protein (4. However, a primary concern are false negatives associated with bone scans, where diffuse metastasis is Knipe H, Prostate cancer skeletal metastases - superscan. Promising results with PSMA-targeted radiopharmaceutical therapy have already been obtained in early-phase studies using various combinations of targeting molecules and radiolabels Prostate cancer (PCa) is the most frequent tumor in men worldwide. Aug 7, 2024 · A superscan is an imaging appearance on a Tc-99m diphosphonate bone scan which occurs as a result of a high ratio of bone to soft tissue tracer accumulation. This patient had a known history of prostate cancer with an elevated PSA of 45 ng/mL. PCa bone metastasis is mainly osteosclerotic, and is caused by a relative excess of osteoblast activity. 3% in a cohort of mixed cancer types up to 2. 108998 Corpus ID: 219762264; Superscan: Superiority of xSPECT/CT over OSEM SPECT/CT in bone scans of prostate cancer patients. 1 About 40–60% of the injected Tc-99m MDP is excreted in the urine. jfqx mzcew rsqdm ulxnzzy lwdhp izgqc zvk tclkv atkzapr jdhuco